Today's best MLB batter vs pitcher matchup picks for Monday, September 21, 2026 are Coby Mayo (Score: 95, 0.400 AVG, 1.400 OPS in 5 career AB vs Trey Yesavage), Andrés Giménez (Score: 73, 0.400 AVG, 1.000 OPS in 5 career AB vs Shane Baz), Vladimir Guerrero Jr. (Score: 57, 0.278 AVG, 0.722 OPS in 18 career AB vs Shane Baz). Rankings are generated by HeatCheck HQ's five factor career H2H scoring model, updated daily.
MLB Batter vs Pitcher Matchups: September 21, 2026
3 game slate, 6 qualified matchups. These career head to head lines stand out.
Hitters to Watch Today
- Coby Mayo: .400 AVG & 1.400 OPS with 1 HR in 5 AB vs. Trey Yesavage | 1+ Hit (minus 153)
- Andrés Giménez: .400 AVG & 1.000 OPS with 0 HR in 5 AB vs. Shane Baz | 1+ Hit (minus 164)
- Vladimir Guerrero Jr.: .278 AVG & 0.722 OPS with 1 HR in 18 AB vs. Shane Baz | 1+ Hit (minus 228)
- Ernie Clement: .273 AVG & 0.606 OPS with 0 HR in 11 AB vs. Shane Baz | 1+ Hit (minus 207)
- Nathan Lukes: .222 AVG & 0.444 OPS with 0 HR in 9 AB vs. Shane Baz | 1+ Hit (minus 197)
- Gunnar Henderson: .200 AVG & 0.533 OPS with 0 HR in 5 AB vs. Trey Yesavage | 1+ Hit (minus 180)
Yesterday's H2H matchups: MLB H2H Matchups: September 20
Tonight's Slate
| Matchup | Pitchers | Time | |---------|----------|—----| | Toronto Blue Jays at Baltimore Orioles | Trey Yesavage vs Shane Baz | 6:35 PM ET | | Washington Nationals at Detroit Tigers | DJ Herz vs River Ryan | 6:40 PM ET | | Minnesota Twins at San Francisco Giants | Zebby Matthews vs Blade Tidwell | 9:45 PM ET |
1. Coby Mayo (BAL) vs Trey Yesavage (RHP)
0.400 AVG, 1.400 OPS in 5 career AB | Oriole Park at Camden Yards | 1+ Hit (minus 153)
Career: 2-for-5 · .400 · 1 HR · 1 XBH · 1.400 OPS · 1 K
Mayo is 2-for-5 (.400) lifetime against Yesavage. He sees this pitcher well and the at bats keep coming back as hits.
Tiny sample, so treat it as directional, not definitive. A home run every 5 at bats in this matchup is well above league pace. Currently listed at 1+ Hit (minus 153).
Bottom line: Mayo owns this matchup against Yesavage. I'm on his hit prop tonight.
2. Andrés Giménez (TOR) vs Shane Baz (RHP)
0.400 AVG, 1.000 OPS in 5 career AB | Oriole Park at Camden Yards | 1+ Hit (minus 164)
Career: 2-for-5 · .400 · 1 XBH · 1.000 OPS · 1 K
Giménez is 2-for-5 (.400) lifetime against Baz. He sees this pitcher well and the at bats keep coming back as hits.
Tiny sample, so treat it as directional, not definitive. Currently listed at 1+ Hit (minus 164).
Bottom line: Giménez owns this matchup against Baz. I'm on his hit prop tonight.
3. Vladimir Guerrero Jr. (TOR) vs Shane Baz (RHP)
0.278 AVG, 0.722 OPS in 18 career AB | Oriole Park at Camden Yards | 1+ Hit (minus 228)
Career: 5-for-18 · .278 · 1 HR · 1 XBH · 0.722 OPS · 2 K
Jr. is 5-for-18 (.278) lifetime against Baz. He sees this pitcher well and the at bats keep coming back as hits.
Moderate sample, and a real pattern is emerging. Currently listed at 1+ Hit (minus 228).
When the sample says this much, you trust it. Jr. has Baz's number. I'm on his hit prop tonight.
Look up any pitcher vs batter career history on the Hitter vs Pitcher dashboard.
4. Ernie Clement (TOR) vs Shane Baz (RHP)
0.273 AVG, 0.606 OPS in 11 career AB | Oriole Park at Camden Yards | 1+ Hit (minus 207)
Career: 3-for-11 · .273 · 0.606 OPS · 2 K · 1 BB
Career batting average against Baz: .273 in 11 AB. Clement has the kind of pitch recognition on this arm that does not show up against the rest of the league.
Moderate sample, and a real pattern is emerging. Currently listed at 1+ Hit (minus 207).
When the sample says this much, you trust it. Clement has Baz's number. I'm on his hit prop tonight.
5. Nathan Lukes (TOR) vs Shane Baz (RHP)
0.222 AVG, 0.444 OPS in 9 career AB | Oriole Park at Camden Yards | 1+ Hit (minus 197)
Career: 2-for-9 · .222 · 0.444 OPS · 1 K
Lukes is 2-for-9 (.222) lifetime against Baz. He sees this pitcher well and the at bats keep coming back as hits.
Small sample, but the dominance is notable. Only 1 strikeout in 9 AB shows the eye is dialed in here. Currently listed at 1+ Hit (minus 197).
Verdict: give me Lukes every time he steps in against Baz. I'm on his hit prop tonight.
6. Gunnar Henderson (BAL) vs Trey Yesavage (RHP)
0.200 AVG, 0.533 OPS in 5 career AB | Oriole Park at Camden Yards | 1+ Hit (minus 180)
Career: 1-for-5 · .200 · 0.533 OPS · 1 K · 1 BB
Henderson is 1-for-5 (.200) lifetime against Yesavage. He sees this pitcher well and the at bats keep coming back as hits.
Tiny sample, so treat it as directional, not definitive. Currently listed at 1+ Hit (minus 180).
Verdict: give me Henderson every time he steps in against Yesavage. I'm on his hit prop tonight.
Hit Props to Consider
- Coby Mayo 1+ Hit (minus 153): 0.400 career AVG vs Trey Yesavage (5 AB). Implied: 60%.
- Andrés Giménez 1+ Hit (minus 164): 0.400 career AVG vs Shane Baz (5 AB). Implied: 62%.
- Vladimir Guerrero Jr. 1+ Hit (minus 228): 0.278 career AVG vs Shane Baz (18 AB). Implied: 70%.
- Ernie Clement 1+ Hit (minus 207): 0.273 career AVG vs Shane Baz (11 AB). Implied: 67%.
- Nathan Lukes 1+ Hit (minus 197): 0.222 career AVG vs Shane Baz (9 AB). Implied: 66%.
- Gunnar Henderson 1+ Hit (minus 180): 0.200 career AVG vs Trey Yesavage (5 AB). Implied: 64%.
Lines via Draftkings. Always shop for the best number. Confirm starting pitcher before betting.
Related Guides
Find More Matchups
These are today's top career advantages, but every game has matchups worth looking into. Check out the Hitter vs Pitcher dashboard to search any batter vs pitcher career history, view full lineup matchups, and explore Statcast data for every game on the slate.
Always confirm lineups and starting pitchers before placing any bets. A different arm on the mound changes the entire matchup profile, and career sample size matters. Matchups with 10 or more at bats carry significantly more weight than those with only five or six.
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Updated as lineups confirm. Full slate at heatcheckhq.io.
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